Tsetse flies kept livestock farming impossible across a 10-million-km² 'tsetse belt' in sub-Saharan Africa, shaping human settlement patterns for millennia.
Tsetse Fly
Glossina morsitans
Reshaped the map of Africa. Gives birth to single larvae. Carries sleeping sickness.
Curated and rated by Sheriff Six-Legs and The Wild Pest field team · Six Legs Score™ (86/100, Outlaw tier) · Published Apr 25, 2026 · Updated Apr 28, 2026 · Released CC BY 4.0
The tsetse fly transmits African sleeping sickness (trypanosomiasis), historically reshaping the geography of human settlement and agriculture across sub-Saharan Africa. Females give birth to a single fully-developed larva at a time — one offspring every 9 days. The 'tsetse belt' has kept entire regions free of cattle for millennia.

Field guide
5 wild facts on file
Tsetse females give birth to a single fully-developed larva at a time — one offspring every 9 days, total 8-10 in a lifetime.
Tsetse flies are viviparous — they nourish their larva internally with milk-like glandular secretions.
Sleeping sickness cases dropped from 37,000 in 1998 to under 1,000 in 2020 — one of the largest disease-control successes of the 21st century.
Both male AND female tsetse flies feed exclusively on blood — most blood-feeding flies have only female blood-feeders.
The tsetse fly is one of the most consequential insects in human history. The species' role in African geography has been described in detail by John Reader's 'Africa: A Biography of the Continent' and is central to the ongoing 'Pan-African Tsetse and Trypanosomiasis Eradication Campaign' (PATTEC) led by the African Union.
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